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Light regulated ligands of neuronal receptors for remote photostimulation

By Javier Adrián

Barcelona,CT,ES
Categories : Area : Medical ... Area : Neurosci... Technology Read...

Evaluation

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We develop light-regulated ligands of neuroreceptors that allow manipulating brain waves with illumination, in order to understand their spatiotemporal dynamics at multiple scales

the aim of project T3.2.4 is to develop light-regulated ligands of neuroreceptors that allow manipulating brain waves with illumination, in order to understand their spatiotemporal dynamics at multiple scales

example of use: we have synthesized and characterized a compound that appears pharmacologically inactive in one configuration (can be added to brain slices without altering wave activity) and that upon illumination activates neuronal receptors and causes an increase in wave frequency and other characteristic wave parameters

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