By Viktor Jirsa
Virtual mouse brain neuroinformatics technology allows systematic exploration of novel signaling pathways
We have extended the open-source simulation software The Virtual Brain (TVB) to whole mouse brain network modeling. It utilises individual diffusion magnetic resonance imaging (dMRI) or tracer-based detailed mouse connectomes from the open access mice brain tracing data from the Allen Institute.
Connectome-based modeling of large-scale brain network dynamics enables causal in silico interrogation of the brain’s structure-function relationship.
This platform can be used to simulate brain activity, such as seizure propagation, stroke and resection and the resting state dynamics in health and disease. The Virtual Mouse Brain (TVMB) enables theoretically driven experimental planning and ways to test predictions in the numerous strains of mice available to study brain function.